Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages.

ABSTRACT: Microbial consortia are an exciting alternative for increasing the performances of bioprocesses for the production of complex metabolic products. However, the functional properties of microbial communities remain challenging to control, considering the complex interaction mechanisms occurring between co-cultured microbial species. Indeed, microbial communities are highly dynamic and can adapt to changing environmental conditions through complex mechanisms, such as phenotypic diversification. We focused on stabilizing a co-culture of Saccharomyces cerevisiae and Escherichia coli in continuous cultures. Our preliminary data pointed out that transient diauxic shifts could lead to stable co-culture by providing periodic fitness advantages to the yeast. Based on a computational toolbox called M

SUBMITTER: Martinez JA 

PROVIDER: S-EPMC9648842 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature