Transcriptome profile of highly osteoblastic/cementoblastic periodontal ligament cell clones.

ABSTRACT:

Background

Heterogeneous cell populations of osteo/cementoblastic (O/C) or fibroblastic phenotypes constitute the periodontal dental ligament (PDL). A better understanding of these PDL cell subpopulations is essential to propose regenerative approaches based on a sound biological rationale.

Objective

Our study aimed to clarify the differential transcriptome profile of PDL cells poised to differentiate into the O/C cell lineage.

Methodology

To characterize periodontal-derived cells with distinct differentiation capacities, single-cell-derived clones were isolated from adult human PDL progenitor cells and their potential to differentiate into osteo/cementoblastic (O/C) phenotype (C-O clones) or fibroblastic phenotype (C-F clones) was assessed in vitro. The transcriptome

SUBMITTER: Saito MT 

PROVIDER: S-EPMC9648949 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature