Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections.

ABSTRACT: Whole cell vaccines are complex mixtures of antigens, immunogens, and sometimes adjuvants that can trigger potent and protective immune responses. In some instances, such as whole cell Bordetella pertussis vaccination, the immune response to vaccination extends beyond the pathogen the vaccine was intended for and contributes to protection against other clinically significant pathogens. In this study, we describe how B. pertussis whole cell vaccination protects mice against acute pneumonia caused by Pseudomonas aeruginosa. Using ELISA and western blot, we identified that B. pertussis whole cell vaccination induces production of antibodies that bind to lab-adapted and clinical strains of P. aeruginosa, regardless of immunization route or adjuvant used. The cross-reactive antigens were identi

SUBMITTER: Blackwood CB 

PROVIDER: S-EPMC9649022 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature