Network Pharmacology and Experimental Validation to Reveal Effects and Mechanisms of Icariin Combined with Nobiletin against Chronic Obstructive Pulmonary Diseases.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is a long-term respiratory disorder marked by restricted airflow and persistent respiratory symptoms. According to previous studies, icariin combined with nobiletin (I&N) significantly ameliorates COPD, but the therapeutic mechanisms remain unclear.

Purpose

The aim of the study is to investigate the therapeutic mechanisms of I&N against COPD using network pharmacology and experimental validation.

Methods

The targets of I&N and related genes of COPD were screened and their intersection was selected. Next, the protein-protein interaction (PPI) networks, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed. Further, a COPD rat model was established to valid

SUBMITTER: Lu R 

PROVIDER: S-EPMC9649313 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature