Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology.

ABSTRACT:

Background

Hearing impairment was recently identified as the most prominent risk factor for dementia. However, the mechanisms underlying the link between hearing impairment and dementia are still unclear.

Methods

We investigated the association of hearing performance with cognitive function, brain structure and cerebrospinal fluid (CSF) proteins in cross-sectional, longitudinal, mediation and genetic association analyses across the UK Biobank (N = 165,550), the Chinese Alzheimer's Biomarker and Lifestyle (CABLE, N = 863) study, and the Alzheimer's Disease Neuroimaging Initiative (ADNI, N = 1770) database.

Findings

Poor hearing performance was associated with worse cognitive function in the UK Biobank and in the CABLE study. Hearing impairment was significantly related

SUBMITTER: Wang HF 

PROVIDER: S-EPMC9649369 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature