Urine proteomic signatures predicting the progression from premalignancy to malignant gastric cancer.

ABSTRACT:

Background

Early detection of gastric cancer (GC) remains challenging. We aimed to examine urine proteomic signatures and identify protein biomarkers that predict the progression of gastric lesions and risk of GC.

Methods

A case-control study was initially designed, covering subjects with GC and gastric lesions of different stages. Subjects were aged 40-69 years, without prior diagnosis of renal or urological diseases. We enrolled a total of 255 subjects, with 123 in the discovery stage from Linqu, China, a high-risk area for GC and 132 in the validation stage from Linqu and Beijing. A prospective study was further designed for a subset of 60 subjects with gastric lesions, which were followed for 297-857 days.

Findings

We identified 43 differentially expressed urine p

SUBMITTER: Fan H 

PROVIDER: S-EPMC9649370 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature