Safety of Antimicrobials for Postexposure Prophylaxis and Treatment of Anthrax: A Review.

ABSTRACT:

Background

Bacillus anthracis, the causative agent for anthrax, poses a potential bioterrorism threat and is capable of causing mass morbidity and mortality. Antimicrobials are the mainstay of postexposure prophylaxis (PEP) and treatment of anthrax. We conducted this safety review of 24 select antimicrobials to identify any new or emerging serious or severe adverse events (AEs) to help inform their risk-benefit evaluation for anthrax.

Methods

Twenty-four antimicrobials were included in this review. Tertiary data sources (e.g. Lactmed, Micromedex, REPROTOX) were reviewed for safety information and summarized to evaluate the known risks of these antimicrobials. PubMed was also searched for published safety information on serious or severe AEs with these antimicrobials; AEs tha

SUBMITTER: Parker CM 

PROVIDER: S-EPMC9649414 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature