Oral mannitol for bowel preparation: a dose-finding phase II study.

ABSTRACT:

Background

Successful bowel preparation (BP) for colonoscopy depends on the instructions, diet, the laxative product, and patient adherence, which all affect colonoscopy quality. Nevertheless, there are no laxatives which combine effectiveness, safety, easy self-administration, good patient acceptance, and low cost. However, mannitol, a sugar alcohol, could be an attractive candidate for use in clinical practice if it is shown to demonstrate adequate efficacy and safety.

Aims

The present phase II dose-finding study compared three doses of mannitol (50, 100, and 150 g) to identify the best dose to be used in a subsequent phase III study.

Methods

The Boston Bowel Preparation Scale, caecal intubation rate, adherence, acceptability, and safety profile, including measureme

SUBMITTER: Spada C 

PROVIDER: S-EPMC9649514 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature