Muscular Swedish mutant APP-to-Brain axis in the development of Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is the most common form of dementia. Notably, patients with AD often suffer from severe sarcopenia. However, their direct link and relationship remain poorly understood. Here, we generated a mouse line, TgAPP_swe^HSA, by crossing LSL (LoxP-STOP-LoxP)-APP_swe with HSA-Cre mice, which express APP_swe (Swedish mutant APP) selectively in skeletal muscles. Examining phenotypes in TgAPP_swe^HSA mice showed not only sarcopenia-like deficit, but also AD-relevant hippocampal inflammation, impairments in adult hippocampal neurogenesis and blood brain barrier (BBB), and depression-like behaviors. Further studies suggest that APP_swe expression in skeletal muscles induces senescence and expressions of senesc

SUBMITTER: Pan JX 

PROVIDER: S-EPMC9649614 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature