Aberrant expression of KDM1A inhibits ferroptosis of lung cancer cells through up-regulating c-Myc.

ABSTRACT: Ferroptosis is a cell death process caused by metabolic dysfunction with the feature of aberrant iron accumulation. Emerging studies have identified that ferroptosis is an important biological function involving in the tumorigenesis, and targeting ferroptosis could provide promising therapeutic targets for lung cancer. However, such therapeutic strategies show limited therapeutic effect owing to drug resistance and other unknown underlying mechanisms. In this study, lysine-specific demethylase 1 (LSD1/KDM1A) was found to be significantly upregulated in lung cancer cells and tissues. The patients with KDM1A downregulation displayed the good prognosis. Using gene set enrichment analysis (GSEA), we demonstrated that KDM1A-associated genes might participate in the regulation of cell ferroptosi

SUBMITTER: Lu C 

PROVIDER: S-EPMC9649633 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature