Prostaglandin E₂ receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka.

ABSTRACT: In vertebrates, female receptivity to male courtship is highly dependent on ovarian secretion of estrogens and prostaglandins. We recently identified female-specific neurons in the medaka (Oryzias latipes) preoptic area that express Npba, a neuropeptide mediating female sexual receptivity, in response to ovarian estrogens. Here we show by transcriptomic analysis that these neurons express a multitude of neuropeptides, in addition to Npba, in an ovarian-dependent manner, and we thus termed them female-specific, sex steroid-responsive peptidergic (FeSP) neurons. Our results further revealed that FeSP neurons express a prostaglandin E₂ receptor gene, ptger4b, in an ovarian estrogen-dependent manner. Behavioral and physiological examination of ptger4b-deficient female medaka found t

SUBMITTER: Fleming T 

PROVIDER: S-EPMC9649691 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature