Kidney tubule health, mineral metabolism and adverse events in persons with CKD in SPRINT.

ABSTRACT:

Background

Measures of kidney tubule health are risk markers for acute kidney injury (AKI) in persons with chronic kidney disease (CKD) during hypertension treatment, but their associations with other adverse events (AEs) are unknown.

Methods

Among 2377 Systolic Blood Pressure Intervention Trial (SPRINT) participants with CKD, we measured at baseline eight urine biomarkers of kidney tubule health and two serum biomarkers of mineral metabolism pathways that act on the kidney tubules. Cox proportional hazards models were used to evaluate biomarker associations with risk of a composite of pre-specified serious AEs (hypotension, syncope, electrolyte abnormalities, AKI, bradycardia and injurious falls) and outpatient AEs (hyperkalemia and hypokalemia).

Results

At baseline,

SUBMITTER: Ascher SB 

PROVIDER: S-EPMC9649818 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature