White matter microstructure and sleep-wake disturbances in individuals at ultra-high risk of psychosis.

ABSTRACT:

Aim

White matter changes in individuals at ultra-high risk for psychosis (UHR) may be involved in the transition to psychosis. Sleep-wake disturbances commonly precede the first psychotic episode and predict development of psychosis. We examined associations between white matter microstructure and sleep-wake disturbances in UHR individuals compared to healthy controls (HC), as well as explored the confounding effect of medication, substance use, and level of psychopathology.

Methods

Sixty-four UHR individuals and 35 HC underwent clinical interviews and diffusion weighted imaging. Group differences on global and callosal mean fractional anisotropy (FA) was tested using general linear modeling. Sleep-wake disturbances were evaluated using the subjective measures disturbed slee

SUBMITTER: Rasmussen JO 

PROVIDER: S-EPMC9649829 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature