DNA methylation signatures of childhood trauma predict psychiatric disorders and other adverse outcomes 17 years after exposure.

ABSTRACT: Childhood trauma is robustly linked to a broad range of adverse outcomes with consequences persisting far into adulthood. We conducted a prospective longitudinal study to predict psychiatric disorders and other adverse outcomes from trauma-related methylation changes 16.9 years after trauma exposure in childhood. Methylation was assayed using a sequencing-based approach that provides near-complete coverage of all 28 million sites in the blood methylome. Methylation data involved 673 assays from 489 participants aged 13.6 years (SD = 1.9) with outcomes measures collected at age 30.4 (SD = 2.26). For a subset of 303 participants we also generated methylation data in adulthood. Trauma-related methylation risk scores (MRSs) significantly predicted adult depression, externalizing problems, nico

SUBMITTER: van den Oord CLJD 

PROVIDER: S-EPMC9649837 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature