Tight Junctions, the Epithelial Barrier, and Toll-like Receptor-4 During Lung Injury.

ABSTRACT: Lung epithelium is constantly exposed to the environment and is critically important for the orchestration of initial responses to infectious organisms, toxins, and allergic stimuli, and maintenance of normal gaseous exchange and pulmonary function. The integrity of lung epithelium, fluid balance, and transport of molecules is dictated by the tight junctions (TJs). The TJs are formed between adjacent cells. We have focused on the topic of the TJ structure and function in lung epithelial cells. This review includes a summary of the last twenty years of literature reports published on the disrupted TJs and epithelial barrier in various lung conditions and expression and regulation of specific TJ proteins against pathogenic stimuli. We discuss the molecular signaling and crosstalk among signa

SUBMITTER: Godbole NM 

PROVIDER: S-EPMC9649847 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature