Orexin, Sleep, Sympathetic Neural Activity, and Cardiovascular Function.

ABSTRACT: Inadequate sleep duration and quality are associated with reduced cardiovascular health and increased mortality. Experimental evidence points to the sympathetic nervous system as a key mediator in the observed relationship between poor sleep and cardiovascular dysfunction. However, brain mechanisms underpinning the impaired sympathetic function associated with poor sleep remain unclear. Recent evidence suggests the central orexin system, particularly orexins A and B and their receptors, have a key regulatory role for sleep in animal and human models. While orexin system activity has been observed to significantly impact sympathetic regulation in animals, the extension of these findings to humans has been difficult due to an inability to directly assess orexin system activity in humans. How

SUBMITTER: Bigalke JA 

PROVIDER: S-EPMC9649879 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature