On-demand regulation and enhancement of the nucleation in acoustic droplet vaporization using dual-frequency focused ultrasound.

ABSTRACT: Acoustic droplet vaporization (ADV) plays an important role in focused ultrasound theranostics. Better understanding of the relationship between the ultrasound parameters and the ADV nucleation could provide an on-demand regulation and enhancement of ADV for improved treatment outcome. In this work, ADV nucleation was performed in a dual-frequency focused ultrasound configuration that consisted of a continuous low-frequency ultrasound and a short high-frequency pulse. The combination was modelled to investigate the effects of the driving frequency and acoustic power on the nucleation rate, efficiency, onset time, and dimensions of the nucleation region. The results showed that the inclusion of short pulsed high-frequency ultrasound significantly increased the nucleation rate with less ener

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9649937 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature