Alterations in whole-brain dynamic functional stability during memory tasks under dexmedetomidine sedation.

ABSTRACT:

Purpose

This study aimed to explore the neurological effects of dexmedetomidine-induced sedation on memory using functional stability, a whole-brain voxel-wise dynamic functional connectivity approach.

Methods

A total of 16 participants (10 men) underwent auditory memory task-related fMRI in the awake state and under dexmedetomidine sedation. Explicit and implicit memory tests were conducted 4 h after ceasing dexmedetomidine administration. One-sample Wilcoxon signed rank test was applied to determine the formation of explicit and implicit memory in the two states. Functional stability was calculated and compared voxel-wise between the awake and sedated states. The association between functional stability and memory performance was also assessed.

Results

In the awake

SUBMITTER: Liu LL 

PROVIDER: S-EPMC9650205 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature