Determination of phage load and administration time in simulated occurrences of antibacterial treatments.

ABSTRACT: The use of phages as antibacterials is becoming more and more common in Western countries. However, a successful phage-derived antibacterial treatment needs to account for additional features such as the loss of infective virions and the multiplication of the hosts. The parameters critical inoculation size (V _F ) and failure threshold time (T _F ) have been introduced to assure that the viral dose (V _ϕ) and administration time (T _ϕ) would lead to the extinction of the targeted bacteria. The problem with the definition of V _F and T _F is that they are non-linear equations with two unknowns; thus, obtaining their explicit values is cumbersome and not unique. T

SUBMITTER: Plunder S 

PROVIDER: S-EPMC9650209 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature