M7G regulator-mediated methylation modification patterns define immune cell infiltration and patient survival

ABSTRACT: Numerous studies have demonstrated the important roles of epigenetic modifications in tumorigenesis, progression and prognosis. However, in hepatocellular carcinoma, the potential link between N7-methylguanosine (m7G) modification and molecular heterogeneity and tumor microenvironment (TME) remains unclear.

Method

We performed a comprehensive evaluation of m7G modification patterns in 816 hepatocellular carcinoma samples based on 24 m7G regulatory factors, identified different m7G modification patterns, and made a systematic correlation of these modification patterns with the infiltration characteristics of immunocytes. Then, we built and validated a scoring tool called m7G score.

Results

In this study, we revealed the presence of three distinct m7G modification patterns

SUBMITTER: Wang L 

PROVIDER: S-EPMC9650241 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature