Prediagnostic biomarkers for early detection of glioma-using case-control studies from cohorts as study approach.

ABSTRACT:

Background

Understanding the trajectory and development of disease is important and the knowledge can be used to find novel targets for therapy and new diagnostic tools for early diagnosis.

Methods

Large cohorts from different parts of the world are unique assets for research as they have systematically collected plasma and DNA over long-time periods in healthy individuals, sometimes even with repeated samples. Over time, the population in the cohort are diagnosed with many different diseases, including brain tumors.

Results

Recent studies have detected genetic variants that are associated with increased risk of glioblastoma and lower grade gliomas specifically. The impact for genetic markers to predict disease in a healthy population has been deemed low, and a releva

SUBMITTER: Wu WY 

PROVIDER: S-EPMC9650466 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature