Heterologous third and fourth dose vaccines reduce severity and mortality in COVID-19 patients during the periods of delta and omicron predominance in Thailand.

ABSTRACT:

Background

The COVID-19 pandemic has evolved quickly, with different variants of concern resulting in the need for countries to offer booster vaccinations. While studies have assessed homologous schedules in detail, the effectiveness of heterologous booster vaccine schedules against severity and mortality with newer variants, remains to be explored fully.

Methods

Utilising a Hospital Information System for COVID-19 established in Chiang Mai, Thailand, we conducted a cohort study by linking patient-level data on laboratory-confirmed COVID-19 cases to the national immunization records, during delta-predominant and omicron predominant periods.

Results

Compared to omicron, COVID-19 cases during delta period were ten times more likely to have severe outcomes and in-hospita

SUBMITTER: Intawong K 

PROVIDER: S-EPMC9650516 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature