Navigating the contested borders between myelodysplastic syndrome and acute myeloid leukemia.

ABSTRACT: Myelodysplastic syndrome and acute myeloid leukemia are heterogeneous myeloid neoplasms which arise from the accumulation of mutations in a myeloid stem cell or progenitor that confer survival or growth advantages. These disease processes are formally differentiated by clinical, laboratory, and morphological presentations, especially with regard to the preponderance of blasts in the peripheral blood or bone marrow (AML); however, they are closely associated through their shared lineage as well as their existence on a spectrum with some cases of MDS displaying increased blasts, a feature that reflects more AML-like behavior, and the propensity for MDS to transform into AML. It is increasingly recognized that the distinctions between these two entities result from the divergent patterns of g

SUBMITTER: Ambinder AJ 

PROVIDER: S-EPMC9650616 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature