Constructing 2D maps of human spinal cord activity and isolating the functional midline with high-density microelectrode arrays.

ABSTRACT: Intraoperative neuromonitoring (IONM) is a widely used practice in spine surgery for early detection and minimization of neurological injury. IONM is most commonly conducted by indirectly recording motor and somatosensory evoked potentials from either muscles or the scalp, which requires large-amplitude electrical stimulation and provides limited spatiotemporal information. IONM may inform of inadvertent events during neurosurgery after they occur, but it does not guide safe surgical procedures when the anatomy of the diseased spinal cord is distorted. To overcome these limitations and to increase our understanding of human spinal cord neurophysiology, we applied a microelectrode array with hundreds of channels to the exposed spinal cord during surgery and resolved spatiotemporal dynamics

SUBMITTER: Russman SM 

PROVIDER: S-EPMC9650777 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature