Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8⁺ T cells in healthy human adults.

ABSTRACT:

Background

Cytomegalovirus (CMV) infection leads to effector memory CD8⁺ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8⁺ T cells in CMV infected healthy young and middle-aged adults has not been fully characterized.

Results

We compared CD8⁺ T cells specific for a CMV epitope (pp65_495-503, NLV) and an influenza A virus (IAV) epitope (M1_58-66, GIL) from the same young and middle-aged healthy adults with serum positive for anti-CMV IgG. Compared to the IAV-specific CD8⁺ T cells, CMV-specific CD8⁺ T cells contained more differentiated effector memory (T_EM and T_EMRA) cells. Isolated CMV-specific cent

SUBMITTER: Lu J 

PROVIDER: S-EPMC9650803 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature