Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks.

ABSTRACT:

Background

To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain water balance drives the behavioral basic instinct to drink. Determining the neural basis of such behaviors, including thirst response, can provide insights into the way brain-wide systems transform sensory inputs into behavioral outputs. However, the neural basis underlying this spontaneous behavior remains unclear. Here, we provide a model of the neural basis of human thirst behavior.

Results

We used fMRI, coupled with functional connectivity analysis and serial-multiple mediation analysis, we found that the physiological need for water is first detected by the

SUBMITTER: Hsu LM 

PROVIDER: S-EPMC9650886 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature