Designing and conducting adaptive trials to evaluate interventions in health services and implementation research: practical considerations.

ABSTRACT: Randomized controlled clinical trials are widely considered the gold standard for evaluating the efficacy or effectiveness of interventions in health care. Adaptive trials incorporate changes as the study proceeds, such as modifying allocation probabilities or eliminating treatment arms that are likely to be ineffective. These designs have been widely used in drug discovery studies but can also be useful in health services and implementation research and have been minimally used. As motivating examples, we use an ongoing adaptive trial and two completed parallel group studies and highlight potential advantages, disadvantages, and important considerations when using adaptive trial designs in health services and implementation research. In addition, we investigate the impact on power and the

SUBMITTER: Lauffenburger JC 

PROVIDER: S-EPMC9650931 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature