Genomic, biochemical and expressional properties reveal strong conservation of the CLCA2 gene in birds and mammals.

ABSTRACT: Recent studies have revealed the dynamic and complex evolution of CLCA1 gene homologues in and between mammals and birds with a particularly high diversity in mammals. In contrast, CLCA2 has only been found as a single copy gene in mammals, to date. Furthermore, CLCA2 has only been investigated in few mammalian species but not in birds. Here, we established core genomic, protein biochemical and expressional properties of CLCA2 in several bird species and compared them with mammalian CLCA2. Chicken, turkey, quail and ostrich CLCA2 were compared to their mammalian orthologues using in silico, biochemical and expressional analyses. CLCA2 was found highly conserved not only at the level of genomic and exon architecture but also in terms o

SUBMITTER: Bartenschlager F 

PROVIDER: S-EPMC9651043 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature