Bacterial Metabolism-Initiated Nanocatalytic Tumor Immunotherapy.

ABSTRACT: The low immunogenicity of tumors remains one of the major limitations of cancer immunotherapy. Herein, we report a bacterial metabolism-initiated and photothermal-enhanced nanocatalytic therapy strategy to completely eradicate primary tumor by triggering highly effective antitumor immune responses. Briefly, a microbiotic nanomedicine, designated as Cu₂O@ΔSt, has been constructed by conjugating PEGylated Cu₂O nanoparticles on the surface of an engineered Salmonella typhimurium strain (ΔSt). Owing to the natural hypoxia tropism of ΔSt, Cu₂O@ΔSt could selectively colonize hypoxic solid tumors, thus minimizing the adverse effects of the bacteria on normal tissues. Upon bacterial metabolism within the tumor, Cu₂O@ΔSt generates H₂S gas and o

SUBMITTER: Wu W 

PROVIDER: S-EPMC9652197 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature