Ontology highlight
ABSTRACT:
SUBMITTER: Okada Y
PROVIDER: S-EPMC9652230 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Okada Yukihiro Y Hosoi Nobutake N Matsuzaki Yasunori Y Fukai Yuuki Y Hiraga Akito A Nakai Junichi J Nitta Keisuke K Shinohara Yoichiro Y Konno Ayumu A Hirai Hirokazu H
Communications biology 20221111 1
Here we describe the microglia-targeting adeno-associated viral (AAV) vectors containing a 1.7-kb putative promoter region of microglia/macrophage-specific ionized calcium-binding adaptor molecule 1 (Iba1), along with repeated miRNA target sites for microRNA (miR)-9 and miR-129-2-3p. The 1.7-kb genomic sequence upstream of the start codon in exon 1 of the Iba1 (Aif1) gene, functions as microglia preferential promoter in the striatum and cerebellum. Furthermore, ectopic transgene expression in no ...[more]