Imbalance of Th17, Treg, and helper innate lymphoid cell in the peripheral blood of patients with rheumatoid arthritis.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) is a chronic inflammatory disease involving a variety of immune cells, including adaptive T and B cells and innate lymphoid cells (ILCs). Understanding the pathogenic role of these immune cells in RA provides new insights into the intervention and treatment of RA.

Methods

A total of 86 patients with RA (RA group) and 50 healthy controls (HC) were included in the study. The immune cells of CD4⁺, CD19⁺ B, NK, Th17, Treg, ILCs, and their subsets (i.e., ILC1s, ILC2s, and ILC3s) were characterized in peripheral blood mononuclear cells by flow cytometry. Cytokines (i.e., IFN-γ, IL-4, IL-10, IL-17A, IL-22, and IL-33) in sera were detected using ELISA. The above immune cells and cytokines were analyzed in patients with dif

SUBMITTER: Wang T 

PROVIDER: S-EPMC9652246 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature