Risk of recurrence after local resection of T1 rectal cancer: a meta-analysis with meta-regression.

ABSTRACT:

Background

T1 rectal cancer (RC) patients are increasingly being treated by local resection alone but uniform surveillance strategies thereafter are lacking. To determine whether different local resection techniques influence the risk of recurrence and cancer-related mortality, a meta-analysis was performed.

Methods

A systematic search was conducted for T1RC patients treated with local surgical resection. The primary outcome was the risk of RC recurrence and RC-related mortality. Pooled estimates were calculated using mixed-effect logistic regression. We also systematically searched and evaluated endoscopically treated T1RC patients in a similar manner.

Results

In 2585 unique T1RC patients (86 studies) undergoing local surgical resection, the overall pooled cumulative

SUBMITTER: Dekkers N 

PROVIDER: S-EPMC9652303 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature