The Staphylococcus aureus cell division protein, DivIC, interacts with the cell wall and controls its biosynthesis.

ABSTRACT: Bacterial cell division is a complex, dynamic process that requires multiple protein components to orchestrate its progression. Many division proteins are highly conserved across bacterial species alluding to a common, basic mechanism. Central to division is a transmembrane trimeric complex involving DivIB, DivIC and FtsL in Gram-positives. Here, we show a distinct, essential role for DivIC in division and survival of Staphylococcus aureus. DivIC spatially regulates peptidoglycan synthesis, and consequently cell wall architecture, by influencing the recruitment to the division septum of the major peptidoglycan synthetases PBP2 and FtsW. Both the function of DivIC and its recruitment to the division site depend on its extracellular domain, which interacts with the cell wall via binding to w

SUBMITTER: Tinajero-Trejo M 

PROVIDER: S-EPMC9652317 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature