Influenza A virus reassortment in mammals gives rise to genetically distinct within-host subpopulations.

ABSTRACT: Influenza A virus (IAV) genetic exchange through reassortment has the potential to accelerate viral evolution and has played a critical role in the generation of multiple pandemic strains. For reassortment to occur, distinct viruses must co-infect the same cell. The spatio-temporal dynamics of viral dissemination within an infected host therefore define opportunity for reassortment. Here, we used wild type and synonymously barcoded variant viruses of a pandemic H1N1 strain to examine the within-host viral dynamics that govern reassortment in guinea pigs, ferrets and swine. The first two species are well-established models of human influenza, while swine are a natural host and a frequent conduit for cross-species transmission and reassortment. Our results show reassortment to be pervasive i

SUBMITTER: Ganti K 

PROVIDER: S-EPMC9652339 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature