Safety evaluations of a synthetic antimicrobial peptide administered intravenously in rats and dogs.

ABSTRACT: The antimicrobial peptide SET-M33 is under study for the development of a new antibiotic against major Gram-negative pathogens. Here we report the toxicological evaluation of SET-M33 administered intravenously to rats and dogs. Dose range finding experiments determined the doses to use in toxicokinetic evaluation, clinical biochemistry analysis, necroscopy and in neurological and respiratory measurements. Clinical laboratory investigations in dogs and rats showed a dose-related increase in creatinine and urea levels, indicating that the kidneys are the target organ. This was also confirmed by necroscopy studies of animal tissues, where signs of degeneration and regeneration were found in kidney when SET-M33 was administered at the highest doses in the two animal species. Neurological toxic

SUBMITTER: Cresti L 

PROVIDER: S-EPMC9652379 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature