Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology.

ABSTRACT: Cognitive deficits are known to be related to most forms of psychopathology. Here, we perform local genetic correlation analysis as a means of identifying independent segments of the genome that show biologically interpretable pleiotropic associations between cognitive dimensions and psychopathology. We identify collective segments of the genome, which we call "meta-loci", showing differential pleiotropic patterns for psychopathology relative to either cognitive task performance (CTP) or performance on a non-cognitive factor (NCF) derived from educational attainment. We observe that neurodevelopmental gene sets expressed during the prenatal-early childhood period predominate in CTP-relevant meta-loci, while post-natal gene sets are more involved in NCF-relevant meta-loci. Further, we demon

SUBMITTER: Lam M 

PROVIDER: S-EPMC9652380 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature