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Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system.

ABSTRACT: A fundamentally novel function proposed for extracellular vesicles (EVs) is to transfer bioactive molecules in intercellular signaling. In this minireview, we discuss recent progress on EV-mediated cargo transfer in the central nervous system (CNS) and major gaps in previous studies. We also suggest a set of experiments necessary for bridging the gaps and establishing the physiological roles of EV-mediated cargo transfer.

SUBMITTER: Wan C

PROVIDER: S-EPMC9652383 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Progress and gaps of extracellular vesicle-mediated intercellular cargo transfer in the central nervous system.

Wan Chun C Stowell Michael H B MHB Shen Jingshi J

Communications biology 20221111 1

A fundamentally novel function proposed for extracellular vesicles (EVs) is to transfer bioactive molecules in intercellular signaling. In this minireview, we discuss recent progress on EV-mediated cargo transfer in the central nervous system (CNS) and major gaps in previous studies. We also suggest a set of experiments necessary for bridging the gaps and establishing the physiological roles of EV-mediated cargo transfer. ...[more]

PMID: 36369335

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