Genomewide association study identifies a novel variant associated with tacrolimus trough concentration in Chinese renal transplant recipients.

ABSTRACT: Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable interindividual variability in pharmacokinetics (PKs). Genetic and clinical factors play important roles in TAC PKs. We enrolled a total of 251 Chinese renal transplant recipients and conducted a genomewide association study (GWAS), linkage disequilibrium (LD), and one-way analysis of variance (ANOVA) to find genetic variants affecting log-transformed TAC trough blood concentration/dose ratio (log[C₀ /D]). In addition, we performed dual luciferase reporter gene assays and multivariate regression models to evaluate the effect of the genetic variants. The GWAS results showed that all 23 genomewide significant single-nucleotide polymorphisms (p < 5 × 10^-8 ) were loca

SUBMITTER: Yang S 

PROVIDER: S-EPMC9652447 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature