Role of methylation-related genes CRYAB and SLC39A11 in the occurrence and development of lung adenocarcinoma.

ABSTRACT:

Background

Previous studies have shown that human crystallin alpha B (CRYAB) is highly expressed in human cancers and associated with poor survival in cancer patients. Here we investigated whether SLC39A11 and CRYAB genes were related to the proliferation and development of lung adenocarcinoma (LUAD) to explore their potential as therapeutic targets and prognostic markers for LUAD.

Methods

CRYAB and SLC39A11 genes were identified from The Cancer Genome Atlas (TCGA) database and Gene Expression Omnibus (GEO) database. The human lung cancer cell lines A549 and H1975 were cultured, transfected, and subjected to RNA extraction. After genomic DNA removal, the RNA was reverse-transcribed. Differences between 2 groups were compared using t-

SUBMITTER: Wang S 

PROVIDER: S-EPMC9652513 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature