Mesenchymal stem cells alleviate aging in vitro and in vivo.

ABSTRACT:

Background

Aging is a natural and multi-factorial phenomenon associated with multiple human pathologies. Mesenchymal stem cells (MSCs) hold great promise in clinical fields of medicine including tissue repair, cardiovascular disease, and brain ischemic injury. The purpose of this study was to explore the roles of MSCs in improving the condition of aging cells, repairing aging tissues and organs, and extending the life span of elderly mice.

Methods

This study was carried out both in vitro and in vivo. We used MSCs to intervene with IMR-90 senescent cells induced by D-galactose and aged C57BL/6 mice.

Results

After 48 hours of co-culturing the aged cells with MSCs, the up-regulated expression of inflammatory factor, interleukin 6 (IL6), and the down-regulat

SUBMITTER: Liu Q 

PROVIDER: S-EPMC9652517 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature