Immunosenescence is a therapeutic target for frailty in older adults: a narrative review.

ABSTRACT:

Background and objective

Aging refers to a progressive decrease in functional performance, leading to increased mortality risk. At present, life expectancy is increasing worldwide and is expected to exceed 80 years by 2040. However, this increase in life expectancy also indicates a rise in the incidence and prevalence of diseases, such as cardiovascular, neurological, musculoskeletal, and oncological diseases, which are associated with aging. The exact underlying mechanisms of aging remain unknown, and whether it is a programmed process or the consequence of an accumulation of stress events remains unclear. Thus, more scientific research is needed to improve the management of complex and frail patients.

Methods

Several databases were searched with the following key words: im

SUBMITTER: Jia H 

PROVIDER: S-EPMC9652526 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature