The silencing of SAAL1 suppresses pneumonia progression via modulating the NLR signaling pathway.

ABSTRACT:

Background

Pneumonia is a severe respiratory disease in both children and elderly people and is commonly accompanied with inflammation and lung injury. In this study, we sought to examine the expression and function of serum amyloid A-like 1 (SAAL1) in a lipopolysaccharide (LPS)-stimulated pneumonia model.

Methods

An LPS-stimulated mouse model and A549 lung cell model were established to examine the effects of SAAL1 in pneumonia. The expression of SAAL1 in pneumonia was analyzed in a Gene Expression Omnibus (GEO) data set and the established mouse model. Lung injury, edema, neutrophil infiltration, and the production of inflammatory factors were measured by histological analysis and enzyme-linked immunosorbent assays (ELISAs). A Gene Set Enrichment Analysis (GSEA) was perfor

SUBMITTER: Chen W 

PROVIDER: S-EPMC9652554 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature