Treatment of progressive nodular histiocytosis: a case report.

ABSTRACT:

Background

Progressive nodular histiocytosis (PNH) is an extremely rare type of non-Langerhans cell histiocytosis, characterized by the emergence of hundreds small to large cutaneous papulonodules without spontaneous remission. It can be life-threatening if pharyngeal and laryngeal mucosa were involved, just as we reported in this case. Disfigurement and disabling are common, whereas current treatment options are of limited efficacy. At present, about 20 reported cases can be found through a PubMed search, fewer with treatment options. In this article, we report a unique case of a patient diagnosed with PNH, in whom regorafenib had a remarkably curative effect.

Case presentation

We present the case of a 21-year-old man who developed lesions on his face, trunk, limbs, and exc

SUBMITTER: Hua M 

PROVIDER: S-EPMC9652561 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature