Integrated analysis identified prognostic microRNAs in breast cancer.

ABSTRACT:

Background

MicroRNAs (miRNAs) play pivotal roles in the development and progression of breast cancer (BC). In this study, we attempted to identify miRNAs associated with BC prognosis and progression via integrated analysis.

Methods

We first screened 83 differentially expressed miRNAs (DEMs) in 1249 BC samples and 151 normal samples. We then validated their roles in expression and prognosis of BC, identified two survival-related DEMs, and established a risk model. The prediction efficiency was assessed in both the training and validation groups. Tissue and cell experiments were conducted to verify the regulatory effects of miR-127 in BC.

Results

The ROC curve indicated good prediction ability with 1-, 3-, and 5-year survival rates of 0.73, 0.72, and 0.72, respectively.

SUBMITTER: Shang C 

PROVIDER: S-EPMC9652801 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature