Bioinformatics analysis of potential key genes and pathways in neonatal necrotizing enterocolitis.

ABSTRACT: To detect differentially expressed genes in patients with neonatal necrotizing enterocolitis (NEC) by bioinformatics methods and to provide new ideas and research directions for the prevention, early diagnosis and treatment of NEC. Gene chip data were downloaded from the Gene Expression Omnibus database. The genes that were differentially expressed in NEC compared with normal intestinal tissues were screened with GEO2R. The functions, pathway enrichment and protein interactions of these genes were analyzed with DAVID and STRING. Then, the core network genes and significant protein interaction modules were detected using Cytoscape software. Overall, a total of 236 differentially expressed genes were detected, including 225 upregulated genes and 11 downregulated genes, and GO and KEGG enrich

SUBMITTER: Liu X 

PROVIDER: S-EPMC9652887 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature