DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome.

ABSTRACT:

Background

COVID-19 infections could be complicated by acute respiratory distress syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of peripheral blood mononuclear cells in COVID-19 with ARDS.

Methods

We recruited 100 COVID-19 patients with ARDS under mechanical ventilation and 33 non-COVID-19 controls between April and July 2020. COVID-19 patients were followed at four time points for 60 days. DNA methylation and immune cell populations were measured at each time point. A multivariate cox proportional risk regression analysis was conducted to identify predictive signatures according to survival.

Results

The comparison of COVID-19 to controls at inclusion revealed the presence of a 14.4% difference in promoter-associated CpGs in genes that

SUBMITTER: Bradic M 

PROVIDER: S-EPMC9652914 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature