Maternal vitamin D during pregnancy and offspring autism and autism-associated traits: a prospective cohort study.

ABSTRACT:

Background

There has been a growing interest in the association between maternal levels of vitamin D during pregnancy and offspring autism. However, whether any associations reflect causal effects is still inconclusive.

Methods

We used data from a UK-based pregnancy cohort study (Avon Longitudinal Study of Parents and Children) comprising 7689 births between 1991 and 1992 with maternal blood vitamin D levels recorded during pregnancy and at least one recorded outcome measure, including autism diagnosis and autism-associated traits. The association between each outcome with seasonal and gestational age-adjusted maternal serum 25-hydroxyvitamin D during pregnancy was estimated using confounder-adjusted regression models. Multiple imputation was used to account for missing data

SUBMITTER: Madley-Dowd P 

PROVIDER: S-EPMC9652971 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature