Phthalates and bone mineral density: a systematic review.

ABSTRACT:

Background

Exposure to endocrine disruptors, such as phthalates, may impact bone mineral density (BMD) through a variety of mechanisms. Studies of phthalate exposure and BMD in humans are scarce.

Objectives

To synthesize published data on the association between phthalate metabolites and BMD in humans and to provide methodological suggestions for future research.

Methods

A single investigator searched PubMed for relevant studies, including observational studies of phthalate exposure and BMD in children and postmenopausal women. Twelve studies were screened with 5 meeting the eligibility criteria and included for review. A quality assessment form was used as a quality measure and key information was extracted from the included studies.

Results

In one prospective

SUBMITTER: Heilmann NZ 

PROVIDER: S-EPMC9652984 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature