Functional brain imaging interventions for radiation therapy planning in patients with glioblastoma: a systematic review.

ABSTRACT:

Rationale

This systematic review aims to synthesise the outcomes of different strategies of incorporating functional biological markers in the radiation therapy plans of patients with glioblastoma to support clinicians and further research.

Methods

The systematic review protocol was registered on PROSPERO (CRD42021221021). A structured search for publications was performed following PRISMA guidelines. Quality assessment was performed using the Newcastle-Ottawa Scale. Study characteristics, intervention methodology and outcomes were extracted using Covidence. Data analysis focused on radiation therapy target volumes, toxicity, dose distributions, recurrence and survival mapped to functional image-guided radiotherapy interventions.

Results

There were 5733 citations scre

SUBMITTER: Ryan JT 

PROVIDER: S-EPMC9653002 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature