Polymorphisms in the K13-Propeller Gene in Artemisinin-Resistant Plasmodium in Mice.

ABSTRACT:

Introduction

Artemisinin-based combination therapies (ACTs) act as first-line antimalarial drugs and play a crucial role in the successful control of falciparum malaria. However, the recent emergence of resistance of Plasmodium falciparum to ACTs in South East Asia is of particular concern. Hence, there is an urgent need to identify the genetic determinants of and understand the molecular mechanisms underpinning such resistance. Artemisinin resistance (AR) is primarily driven by the mutations in the P. falciparum K13 protein, which is widely recognized as the major molecular marker of AR. However, association of K13 mutations with in vivo AR has been ambiguous due to the absence of a tractable model.

Methods

In this study, we have successfully produced a

SUBMITTER: Zheng S 

PROVIDER: S-EPMC9653030 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature